Pages tagged "IARC"
Monsanto Co. started an agricultural revolution with its “Roundup Ready” seeds, genetically modified to resist the effects of its blockbuster herbicide called Roundup. That ability to kill weeds while leaving desirable crops intact helped the company turn Roundup’s active ingredient, the chemical glyphosate, into one of the world’s most-used crop chemicals. When that heavy use raised health concerns, Monsanto noted that the herbicide’s safety had repeatedly been vetted by outsiders. But now there’s new evidence that Monsanto’s claims of rigorous scientific review are suspect.
Dozens of internal Monsanto emails, released on Aug. 1 by plaintiffs’ lawyers who are suing the company, reveal how Monsanto worked with an outside consulting firm to induce the scientific journal Critical Reviews in Toxicology to publish a purported “independent” review of Roundup’s health effects that appears to be anything but. The review, published along with four subpapers in a September 2016 special supplement, was aimed at rebutting the 2015 assessment by the International Agency for Research on Cancer (IARC) that glyphosate is a probable human carcinogen. That finding by the cancer-research arm of the World Health Organization led California last month to list glyphosate as a known human carcinogen. It has also spurred more than 1,000 lawsuits in state and federal courts by plaintiffs who claim they contracted non-Hodgkin lymphoma from Roundup exposure.
Monsanto disclosed that it paid Intertek Group Plc’s consulting unit to develop the review supplement, entitled “An Independent Review of the Carcinogenic Potential of Glyphosate.” But that was the extent of Monsanto’s involvement, the main article said. “The Expert Panelists were engaged by, and acted as consultants to, Intertek, and were not directly contacted by the Monsanto Company,” according to the review’s Declaration of Interest statement. “Neither any Monsanto company employees nor any attorneys reviewed any of the Expert Panel’s manuscripts prior to submission to the journal.”
Monsanto’s internal emails tell a different story. The correspondence shows the company’s chief of regulatory science, William Heydens, and other Monsanto scientists were heavily involved in organizing, reviewing, and editing drafts submitted by the outside experts. At one point, Heydens even vetoed explicit requests by some of the panelists to tone down what one of them wrote was the review’s “inflammatory” criticisms of IARC.
Glyphosate, an herbicide and the active ingredient in Monsanto Co’s popular Roundup weed killer, will be added to California’s list of chemicals known to cause cancer effective July 7, the state’s Office of Environmental Health Hazard Assessment (OEHHA) said on Monday.
Monsanto vowed to continue its legal fight against the designation, required under a state law known as Proposition 65, and called the decision “unwarranted on the basis of science and the law.”
The listing is the latest legal setback for the seeds and chemicals company, which has faced increasing litigation over glyphosate since the World Health Organization’s International Agency for Research on Cancer said that it is “probably carcinogenic” in a controversial ruling in 2015.
Earlier this month, Reuters reported that the scientist leading the IARC’s review knew of fresh data showing no link between glyphosate and cancer. But he never mentioned it, and the agency did not take the information into account because it had yet to be published in a scientific journal. The IARC classed glyphosate as a “probable carcinogen,” the only major health regulator to do so.
Dicamba, a weed killer designed for use with Monsanto’s next generation of biotech crops, is under scrutiny in Arkansas after the state’s plant board voted last week to ban the chemical.
OEHHA said the designation of glyphosate under Proposition 65 will proceed following an unsuccessful attempt by Monsanto to block the listing in trial court and after requests for stay were denied by a state appellate court and the California’s Supreme Court.
Reuters is reporting that Monsanto is demanding a sit-down with members of the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC). This international scientific body is being called on the carpet for reporting that Monsanto’s most widely sold herbicide, which is inextricably linked to the majority of their genetically engineered products, is probably carcinogenic to humans.
In a DO-YOU-KNOW-WHO-WE-ARE moment, Monsanto’s vice president of global regulatory affairs Philip Miller said the following in interview:"We question the quality of the assessment. The WHO has something to explain." [emphasis mine]
Evidence for the carcinogenicity of Glyphosate comes from a peer-reviewed study published in March of 2015 in the respected journal The Lancet Oncology.Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate
Glyphosate is a broad-spectrum herbicide, currently with the highest production volumes of all herbicides. It is used in more than 750 different products for agriculture, forestry, urban, and home applications. Its use has increased sharply with the development of genetically modified glyphosate-resistant crop varieties. Glyphosate has been detected in air during spraying, in water, and in food. There WAS limited evidence in humans for the carcinogenicity of glyphosate.
Glyphosate has been detected in the blood and urine of agricultural workers, indicating absorption. Soil microbes degrade glyphosate to aminomethylphosphoric acid (AMPA). Blood AMPA detection after poisonings suggests intestinal microbial metabolism in humans. Glyphosate and glyphosate formulations induced DNA and chromosomal damage in mammals, and in human and animal cells in vitro. One study reported increases in blood markers of chromosomal damage (micronuclei) in residents of several communities after spraying of glyphosate formulations.
Recently, I attended a talk by Monsanto’s Dr. William “Bill” Moar who presented the latest project in their product pipeline dealing with RNA. Most notably, he also spoke about Monsanto’s efforts to educate citizens about the scientific certainty of the safety of their genetically engineered products. The audience was mostly agricultural students many of whom were perhaps hoping for the only well-paid internships and jobs in their field.
One student asked what Monsanto was doing to counter the “bad science” around their work. Dr. Moar, perhaps forgetting that this was a public event, then revealed that Monsanto indeed had “an entire department” (waving his arm for emphasis) dedicated to “debunking” science which disagreed with theirs. As far as I know this is the first time that a Monsanto functionary has publically admitted that they have such an entity which brings their immense political and financial weight to bear on scientists who dare to publish against them. The Discredit Bureau will not be found on their official website.
The challenge for Monsanto’s Discredit Bureau is steep in attacking the unimpeachably respected Lancet and the international scientific bodies of WHO and IARC. However, they have no choice but to attack since the stakes are so very high for them. Glyphosate is their hallmark product upon which the majority of their profits are based. Make no mistake, this is extremely bad news for Monsanto.
Monsanto holds up the sheer abundance of their own well-funded studies citing the safety of Glyphosate, done over only the past twenty years which is a short period of time in scientific inquiry particularly when dissenting research is actively suppressed. They also hold up the findings of regulatory bodies, particularly in the United States where the revolving door between agrochemical corporations and government spins at high speed.
Critics of the agrochemical industry have often cited the history of these corporations who rush their products to market with protestations of safety only to discover down the road that they have become persistent ecological and health nightmares. We are seeing the end of that road for Glyphosate.
UPDATE: Read the second diary in what is rapidly turning into a series. USDA Tentacle of Monsanto 'Discredit Bureau'?
Photo from Flickr.